2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide

Base Information

• Chemical Name: 2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide
• CAS No.: 127446-45-1
• Molecular Formula: C₁₈H₂₀N₂O₂
• Molecular Weight: 296.369
• Mol file: 127446-45-1.mol

Synonyms:2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide

Chemical Property of 2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide

There total 1 articles about 2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(pivaloylamino)pyridine (86847-59-8) + N-methoxy-N,4-dimethylbenzamide (122334-36-5) → 2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide (127446-45-1)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, 0 deg C, 3 h; 2) THF, room temp., 2 h;

DOI:10.1021/jo00302a049

Reference yield: 73.0%

t-butyl lithioacetate (150942-98-6) + 2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide (127446-45-1) → 2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester (127446-46-2)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo00302a049

Reference yield:

2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide (127446-45-1) → 4-(4-Methylphenyl)-1,8-naphthyridin-2-one (127446-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / tetrahydrofuran / -78 - 20 °C

2: 84 percent / 3N-aq. HCl / dioxane / 72 h / Heating

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jo00302a049

upstream raw materials:

2-(pivaloylamino)pyridine

N-methoxy-N,4-dimethylbenzamide

Downstream raw materials:

2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

4-(4-Methylphenyl)-1,8-naphthyridin-2-one