(E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide

Base Information

• Chemical Name: (E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide
• CAS No.: 454479-20-0
• Molecular Formula: C₁₅H₁₄FNO₃S
• Molecular Weight: 307.345
• Mol file: 454479-20-0.mol

Synonyms:(E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide

Chemical Property of (E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide

There total 5 articles about (E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-trans-(4-Methoxyphenyl)ethenesulfonyl Chloride (315495-30-8) + 4-fluoroaniline (371-40-4) → (E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide (454479-20-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm400575x

Reference yield: 49.0%

2-[N-(4-fluorophenyl)sulfamoyl]acetic acid (904627-07-2) + 4-methoxy-benzaldehyde (123-11-5) → (E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide (454479-20-0)

Guidance literature:

With acetic acid; benzylamine; at 20 ℃; for 8h; Inert atmosphere Reflux; Inert atmosphere;

DOI:10.1021/jm400575x

Reference yield:

4-Methoxystyrene (637-69-4,24936-44-5) → (E)-N-(4-fluorophenyl)-2-(4-methoxyphenyl)ethenesulfonamide (454479-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With sulfuryl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm400575x

upstream raw materials:

4-Methoxystyrene

2-trans-(4-Methoxyphenyl)ethenesulfonyl Chloride

4-fluoroaniline

ethyl 2-[N-(4-fluorophenyl)sulfamoyl]acetate