L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

Base Information

Chemical Name:L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide
CAS No.:138571-27-4
Molecular Formula:C₃₄H₅₈N₄O₄
Molecular Weight:586.859
Hs Code.:

Synonyms:L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

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Chemical Property of L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

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Technology Process of L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

There total 6 articles about L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 138571-26-3
N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

: 138571-27-4
L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

Guidance literature:: With hydrazine hydrate; In ethanol; for 3h; Heating;
DOI:10.1021/jm00083a006

Reference yield:

: 105852-64-0
(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

: 138571-27-4
L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 34 percent / N-hydroxybenzotriazole, DCC / CH₂Cl₂ / Ambient temperature

2: 68 percent / hydrazine hydrate / ethanol / 3 h / Heating

With benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;
DOI:10.1021/jm00083a006

Reference yield:

: 3844-54-0
L-2-aminohexanoic acid-methyl ester hydrochloride

: 138571-27-4
L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethylamine, N-hydroxybenzotriazole, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 2.) CH₂Cl₂, RT, overnight

2: 60 percent / aq. HCl / acetone / 5 h / Heating

3: 34 percent / N-hydroxybenzotriazole, DCC / CH₂Cl₂ / Ambient temperature

4: 68 percent / hydrazine hydrate / ethanol / 3 h / Heating

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm00083a006