benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester

Base Information

• Chemical Name: benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester
• CAS No.: 851961-94-9
• Molecular Formula: C₁₇H₂₄O₆S
• Molecular Weight: 356.44
• Mol file: 851961-94-9.mol

Synonyms:benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester

Chemical Property of benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester

There total 4 articles about benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzoic acid 2-{2-[2-(2-bromo-ethoxy)-ethoxy]-ethoxy}-ethyl ester (851961-89-2) + tiolacetic acid (507-09-5) → benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester (851961-94-9)

Guidance literature:

tiolacetic acid; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

benzoic acid 2-{2-[2-(2-bromo-ethoxy)-ethoxy]-ethoxy}-ethyl ester; In N,N-dimethyl-formamide; for 0.5h;

DOI:10.1021/ja042929f

Reference yield:

Tetraethylene glycol (112-60-7) → benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester (851961-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 65 percent / pyridine / CH₂Cl₂ / 24 h / 20 °C

2.1: 97 percent / N-bromosuccinimide; triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

3.1: sodium hydride / dimethylformamide / 0.5 h

3.2: 91 percent / dimethylformamide / 0.5 h

With pyridine; N-Bromosuccinimide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja042929f

Reference yield:

benzoyl chloride (98-88-4) → benzoic acid 2-{2-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-ethoxy}-ethyl ester (851961-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 65 percent / pyridine / CH₂Cl₂ / 24 h / 20 °C

2.1: 97 percent / N-bromosuccinimide; triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

3.1: sodium hydride / dimethylformamide / 0.5 h

3.2: 91 percent / dimethylformamide / 0.5 h

With pyridine; N-Bromosuccinimide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja042929f

upstream raw materials:

benzoic acid 2-{2-[2-(2-bromo-ethoxy)-ethoxy]-ethoxy}-ethyl ester

tiolacetic acid

Tetraethylene glycol

benzoyl chloride

Downstream raw materials:

2-(2-(2-(2-(pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)ethan-1-ol

2-{3,5-dichloro-4-[2-(2-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenylamino}-benzoic acid tert-butyl ester