Diethyl -forMylMalonate

Base Information

• Chemical Name: Diethyl -forMylMalonate
• CAS No.: 33142-25-5
• Molecular Formula: C₈H₁₂O₅
• Molecular Weight: 188.18
• Mol file: 33142-25-5.mol

Synonyms:diethyl α-formylmalonate

Chemical Property of Diethyl -forMylMalonate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl -forMylMalonate

There total 3 articles about Diethyl -forMylMalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoyl(dichloro)acetaldehyde (160663-32-1) + diethyl malonate (105-53-3) → diethyl α-formylmalonate (33142-25-5) + 2,2-dichloroacetophenone (2648-61-5)

Guidance literature:

diethyl malonate; With sodium hydride; In diethyl ether; for 1h; Heating;

benzoyl(dichloro)acetaldehyde; In diethyl ether; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1007/BF02496260

Reference yield:

2,2-dichloro-3-oxo-propionic acid ethyl ester (86164-39-8) + diethyl malonate (105-53-3) → diethyl α-formylmalonate (33142-25-5) + ethyl 1,1-dichloroacetate (535-15-9)

Guidance literature:

diethyl malonate; With sodium hydride; In diethyl ether; for 1h; Heating;

2,2-dichloro-3-oxo-propionic acid ethyl ester; In diethyl ether; at 20 ℃;

DOI:10.1007/BF02496260

Reference yield:

prop-2-ene-1,1,3-tricarboxylic acid triethyl ester (121511-39-5) + ozone (10028-15-6) + ethyl acetate (141-78-6) → glyoxylic acid ethyl ester (924-44-7) + diethyl α-formylmalonate (33142-25-5) + oxalic acid (144-62-7,97993-78-7)

Guidance literature:

at 0 ℃;

upstream raw materials:

prop-2-ene-1,1,3-tricarboxylic acid triethyl ester

ozone

ethyl acetate

benzoyl(dichloro)acetaldehyde

Downstream raw materials:

diethyl benzalmalonate

ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxilate

diethyl 2-(chloromethylene)malonate

formic acid