ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate

Base Information

• Chemical Name: ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate
• CAS No.: 115981-92-5
• Molecular Formula: C₁₆H₂₅NO₄
• Molecular Weight: 295.379
• Mol file: 115981-92-5.mol

Synonyms:ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate

Chemical Property of ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate

There total 1 articles about ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(m-methoxyphenyl)-2-butenoate + propan-1-ol-3-amine (156-87-6) → ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate (115981-92-5)

Guidance literature:

In ethanol; for 168h; Ambient temperature;

DOI:10.1021/jm00118a028

Reference yield: 82.0%

formic acid (64-18-6) + ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate (115981-92-5) → ethyl 2-(m-methoxyphenyl)-3-amino>butanoate (115981-93-6)

Guidance literature:

In acetic anhydride; at 70 ℃; for 1.5h;

DOI:10.1021/jm00118a028

Reference yield:

ethyl 2-(m-methoxyphenyl)-3-<(3'-hydroxypropyl)amino>butanoate (115981-92-5) → (2S,3S)-1-Allyl-3-(3-methoxy-phenyl)-2-methyl-piperidine-3-carboxylic acid ethyl ester (115982-03-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 82 percent / acetic anhydride / 1.5 h / 70 °C

2: 98 percent / KHCO₃ / methanol; H₂O / 16 h / Ambient temperature

3: 98 percent / pyridine / 2 h / 0 °C

4: 67 percent / NaI / acetone / 5 h / Ambient temperature

5: 30 percent / KH / dimethylformamide / 0 deg C, 8 h; RT, 16 h

6: HCl / ethanol / 24 h / Heating

7: KHCO₃

With hydrogenchloride; potassium hydride; potassium hydrogencarbonate; sodium iodide; In pyridine; methanol; ethanol; water; acetic anhydride; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm00118a028

upstream raw materials:

propan-1-ol-3-amine

Downstream raw materials:

ethyl 2-(m-methoxyphenyl)-3-amino>butanoate

(2S,3S)-3-(3-Methoxy-phenyl)-1,2-dimethyl-piperidine-3-carboxylic acid ethyl ester

ethyl 2-(m-methoxyphenyl)-3-butanoate

ethyl 2-(m-methoxyphenyl)-3-butanoate