(R)-licochalcone E

Base Information

Chemical Name:(R)-licochalcone E
CAS No.:1337973-11-1
Molecular Formula:C₂₁H₂₂O₄
Molecular Weight:338.403
Hs Code.:

Synonyms:(R)-licochalcone E

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Chemical Property of (R)-licochalcone E

Chemical Property:

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Technology Process of (R)-licochalcone E

There total 10 articles about (R)-licochalcone E which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1337973-29-1
(E)-3-(2-methoxy-4-(methoxymethoxy)-5-((R)-3-methylbut-3-en-2-yl)phenyl)-1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)prop-2-en-1-one

: 1337973-11-1
(R)-licochalcone E

Guidance literature:: With hydrogenchloride; water; In methanol; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1227484-15-2
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

: 1337973-11-1
(R)-licochalcone E

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / tetrahydrofuran / 1.25 h / -78 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; diethyl ether / 0.67 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.2 h / -78 °C / Inert atmosphere

3.2: 6 h / -78 - 20 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

4.2: pH 2 - 3 / Inert atmosphere

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C / Inert atmosphere

6.1: tetrahydrofuran; diethyl ether / 3 h / 0 °C / Inert atmosphere

6.2: Inert atmosphere

7.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 20 °C / Inert atmosphere

7.2: 4 h / 20 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

9.1: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere

10.1: potassium hydroxide / ethanol; water / 48 h / 20 °C / Inert atmosphere

11.1: hydrogenchloride; water / methanol / 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; dihydrogen peroxide; sodium hexamethyldisilazane; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; 7.2: Wittig reaction / 10.1: Claisen-Schmidt condensation;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1337973-15-5
(S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

: 1337973-11-1
(R)-licochalcone E

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 3 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 20 °C / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere

6.1: potassium hydroxide / ethanol; water / 48 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / methanol / 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; water; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; 3.2: Wittig reaction / 6.1: Claisen-Schmidt condensation;
DOI:10.1007/s12272-011-0805-9