2-(4-chlorophenyl)-2-methoxyacetonitrile

Base Information

• Chemical Name: 2-(4-chlorophenyl)-2-methoxyacetonitrile
• CAS No.: 33225-02-4
• Molecular Formula: C₉H₈ClNO
• Molecular Weight: 181.622
• Mol file: 33225-02-4.mol

Synonyms:2-(4-chlorophenyl)-2-methoxyacetonitrile

Chemical Property of 2-(4-chlorophenyl)-2-methoxyacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-2-methoxyacetonitrile

There total 3 articles about 2-(4-chlorophenyl)-2-methoxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + 4-chlorobenzaldehyde dimethyl acetal (3395-81-1) → 2-(4-chlorophenyl)-2-methoxyacetonitrile (33225-02-4)

Guidance literature:

In nitromethane; at 60 ℃; for 20h; under 6000600 Torr;

DOI:10.1055/s-2006-947347

Reference yield: 5.6%

methanol (67-56-1) + cyano(4-chlorophenyl)methyl acetate (99074-23-4) → Methyl 4-chlorobenzoate (1126-46-1) + 2-(4-chlorophenyl)propionitrile (2184-88-5) + 2-(4-chlorophenyl)-2-methoxyacetonitrile (33225-02-4)

Guidance literature:

for 2h; Ambient temperature; Irradiation; photoinduced decarboxylation;

Reference yield:

→ 2-(4-chlorophenyl)-2-methoxyacetonitrile (33225-02-4)

Guidance literature:

Entspr. Amid, SOCl2;

upstream raw materials:

methanol

cyano(4-chlorophenyl)methyl acetate

trimethylsilyl cyanide

4-chlorobenzaldehyde dimethyl acetal