2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate

Base Information

• Chemical Name: 2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate
• CAS No.: 291537-03-6
• Molecular Formula: C₂₈H₂₁IN₂O₃S
• Molecular Weight: 592.457
• Mol file: 291537-03-6.mol

Synonyms:2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate

Chemical Property of 2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate

There total 8 articles about 2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenylhydrazine hydrochloride (59-88-1) + 2-[3-(N,N-dimethylamino)-2-(2-iodophenyl)acryloyl]phenyl tosylate (291536-95-3) → 2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate (291537-03-6)

Guidance literature:

With sodium carbonate; acetic acid; In methanol; water; at 145 ℃; for 5h; pH=4;

DOI:10.1021/jo025767j

Reference yield: 90.0%

phenylhydrazine (100-63-0) + Toluene-4-sulfonic acid 2-[(E)-3-dimethylamino-2-(2-iodo-phenyl)-acryloyl]-phenyl ester → 2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate (291537-03-6)

Guidance literature:

With sodium carbonate; acetic acid; In methanol; water; at 140 ℃; pH=4;

DOI:10.1016/S0040-4039(00)00621-3

Reference yield:

2-formylphenyl tosylate (19820-56-5) → 2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl tosylate (291537-03-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / H₂O; acetonitrile / 10 h / 20 °C

2: NaH / dimethylformamide / 3.5 h / -19 °C

3: conc.HCl / methanol; H₂O / 110 °C

4: 46 percent / toluene / 90 °C

5: 90 percent / Na₂CO₃; HOAc / methanol; H₂O / 5 h / 145 °C / pH 4

With hydrogenchloride; sodium hydride; sodium carbonate; acetic acid; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4: Vilsmeier-Haack reaction;

DOI:10.1021/jo025767j

upstream raw materials:

phenylhydrazine

phenylhydrazine hydrochloride

2-[3-(N,N-dimethylamino)-2-(2-iodophenyl)acryloyl]phenyl tosylate

2-formylphenyl tosylate

Downstream raw materials:

5-(2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

1,4-diphenylpyrazole-5-(2-hydroxyphenyl)pyrazole