1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid methyl ester
• CAS No.: 20845-23-2
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.164
• Hs Code.: 2933399090
• Mol file: 20845-23-2.mol

Synonyms:Isonicotinicacid, 1,2-dihydro-1-methyl-2-oxo-, methyl ester (7CI,8CI);1-Methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid methyl ester;4-Methoxycarbonyl-1-methyl-2(1H)-pyridone

Chemical Property of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid methyl ester

Chemical Property:

• PSA: 48.30000
• LogP: 0.17190
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid methyl ester

There total 7 articles about 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid (33972-97-3) + methyl iodide (74-88-4) → methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (20845-23-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 66.0%

2-oxo-1,2-dihydropyridine-4-carboxylic acid (22282-72-0) + methyl iodide (74-88-4) → methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (20845-23-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield: 46.0%

methyl iodide (74-88-4) → methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (20845-23-2)

Guidance literature:

methyl 2-hydroxypyridine-4-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

methanol

1-Methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl chloride

1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid

methyl iodide

Downstream raw materials:

methanol

1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid

1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid hydrazide

4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

Refernces

• 1、 -. "MGLUR5 MODULATORS". Page/Page column 65. . Retrieved 2008/06/13.
• 2、 -. "SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS". Page/Page column 102-103. . Retrieved 2008/06/13.