7-Methoxy-1H-pyrrolo[2,3-C]pyridine

Base Information

• Chemical Name: 7-Methoxy-1H-pyrrolo[2,3-C]pyridine
• CAS No.: 160590-40-9
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• Hs Code.: 2933990090
• European Community (EC) Number: 640-945-1
• DSSTox Substance ID: DTXSID90452453
• Nikkaji Number: J1.761.269G
• Wikidata: Q72485926
• Mol file: 160590-40-9.mol

Synonyms:7-METHOXY-1H-PYRROLO[2,3-C]PYRIDINE;160590-40-9;7-methoxy-6-azaindole;1H-PYRROLO[2,3-C]PYRIDINE, 7-METHOXY-;MFCD09864857;1H-Pyrrolo[2,3-c]pyridine,7-methoxy-(9CI);1H-Pyrrolo[2,3-c]pyridine,7-methoxy-;SCHEMBL1150533;7-Methoxy-6-azaindole, 98%;AMY9998;DTXSID90452453;RHEGHTSBMVYYAM-UHFFFAOYSA-N;AKOS006349675;PB25221;PS-4833;BL000868;SY064855;CS-0043583;FT-0651759;EN300-372048;A810152;W-205865;Z1203734686

Chemical Property of 7-Methoxy-1H-pyrrolo[2,3-C]pyridine

Chemical Property:

• Melting Point: 110-114℃
• Boiling Point: 304.145 °C at 760 mmHg
• PKA: 14.15±0.40(Predicted)
• Flash Point: 104.512 °C
• PSA: 37.91000
• Density: 1.244 g/cm³
• LogP: 1.57150
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

7-Methoxy-1H-pyrrolo[2,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC=CC2=C1NC=C2

Technology Process of 7-Methoxy-1H-pyrrolo[2,3-C]pyridine

There total 6 articles about 7-Methoxy-1H-pyrrolo[2,3-C]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-[(2-di-N,N-methylamino)vinyl]-2-methoxy-3-nitropyridine (364046-14-0) → 7-methoxy-1H-pyrrolo[2,3-c]pyridine (160590-40-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 0.25h; under 775.722 Torr;

DOI:10.1021/jo0155613

Reference yield: 46.0%

sodium methylate (124-41-4) + 7-chloro-1H-pyrrolo[2,3-c]pyridine (357263-41-3) → 7-methoxy-1H-pyrrolo[2,3-c]pyridine (160590-40-9)

Guidance literature:

at 110 ℃; for 4h; Microwave irradiation;

Reference yield: 21.27%

2-methoxy-3-nitropyridine (20265-35-4) + vinyl magnesium bromide (1826-67-1) → 7-methoxy-1H-pyrrolo[2,3-c]pyridine (160590-40-9)

Guidance literature:

In tetrahydrofuran; at -78 - -20 ℃;

upstream raw materials:

4-[(2-di-N,N-methylamino)vinyl]-2-methoxy-3-nitropyridine

2-methoxy-3-nitropyridine

vinyl magnesium bromide

2-chloro-3-nitro-4-methylpyridine

Downstream raw materials:

1-N-benzyloxymethyl-7-methoxypyrrolo[2,3-c]pyridine

1-N-benzyloxymethyl-3-bromo-7-methoxypyrrolo[2,3-c]pyridine

(1S)-1-(1-N-benzyloxymethyl-7-methoxypyrrolo[2,3-c]pyridin-3-yl)-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol