Technology Process of 1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol
There total 10 articles about 1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-bromo-3,4,5-trimethoxybenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
1-isopropoxy-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1016/j.bmc.2013.08.035
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Sealed tube
4.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
6.2: 12 h / 20 °C / Inert atmosphere
With
aluminum (III) chloride; n-butyllithium; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.08.035
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphorus pentoxide; methanesulfonic acid / 12 h / Inert atmosphere
2.1: trimethylammonium heptachlorodialuminate / dichloromethane / 1 h / 80 °C / Inert atmosphere; Microwave irradiation
3.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
4.2: 12 h / 20 °C / Inert atmosphere
With
n-butyllithium; methanesulfonic acid; phosphorus pentoxide; trimethylammonium heptachlorodialuminate; caesium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.08.035
![1-isopropoxy-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one](/Databaselist/images/loading.webp)
