1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene

Base Information

Chemical Name:1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene
CAS No.:1073537-40-2
Molecular Formula:C₂₄H₃₀O₅
Molecular Weight:398.499
Hs Code.:

Synonyms:1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene

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Chemical Property of 1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene

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Technology Process of 1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene

There total 13 articles about 1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1073537-39-9
1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

: 1073537-40-2
1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene

Guidance literature:: With acetic acid; for 12h; Heating;
DOI:10.1016/j.bmc.2008.07.050

Reference yield: 84.0%

: 1073537-35-5
1-isopropoxy-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 1073537-40-2
1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene

Guidance literature:: 1-bromo-3,4,5-trimethoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-isopropoxy-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 20h;
DOI:10.1016/j.tetlet.2018.12.033

Reference yield:

: 75792-35-7
2-isopropoxy-3-methoxy-benzaldehyde

: 1073537-40-2
1-isopropoxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)-8,9-dihydro-7H-benzocycloheptene

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Sealed tube

3.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

6.1: acetic acid / 6 h / Inert atmosphere; Reflux

With aluminum (III) chloride; n-butyllithium; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.08.035