1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

Base Information

Chemical Name:1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole
CAS No.:1350324-56-9
Molecular Formula:C₁₆H₂₉IN₂OSi
Molecular Weight:423.385
Hs Code.:

Synonyms:1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

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Chemical Property of 1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

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Technology Process of 1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

There total 6 articles about 1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865-50-9
iodomethane-d3

: 1257997-18-4
1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole

: 1350324-56-9
1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

Guidance literature:: 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h;

iodomethane-d3; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1350324-56-9
1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

2.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 0.5 h / -78 °C

With 1H-imidazole; dmap; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane;

Reference yield:

: 23511-05-9
toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester

: 1350324-56-9
1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 100 °C

2.1: water; pyridinium p-toluenesulfonate / acetone / 16 h / 65 °C

3.1: ethanol; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

4.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

5.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C

5.2: 0.5 h / -78 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; ethanol; water; pyridinium p-toluenesulfonate; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetone;