N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine

Base Information

• Chemical Name: N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine
• CAS No.: 1242002-08-9
• Molecular Formula: C₁₃H₁₆F₃NO
• Molecular Weight: 259.271
• Mol file: 1242002-08-9.mol

Synonyms:N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine

Chemical Property of N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine

There total 4 articles about N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

methanol (67-56-1) + C13H15F3N(1+) → N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine (1242002-08-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201502084

Reference yield:

CF3O3S(1-)*C12H16NO(1+) (156722-68-8) + (trifluoromethyl)trimethylsilane (81290-20-2) → N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine (1242002-08-9)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

DOI:10.1007/s11172-010-0039-x

Reference yield:

tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate (1052713-78-6) → N-benzyl-2-[(methoxy)methyl]-2-(trifluoromethyl)pyrrolidine (1242002-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 5 h / -15 - 40 °C / Inert atmosphere

3.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/chem.201502084

upstream raw materials:

CF₃O₃S^(1-)*C₁₂H₁₆NO⁽¹⁺⁾

(trifluoromethyl)trimethylsilane

tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate

methanol

Downstream raw materials:

1-benzyl-2-trifluoromethylpyrrolidine

1-benzyl-2-phenacyl-2-trifluoromethylpyrrolidine

methyl 2-(1-benzyl-2-trifluoromethylpyrrolidin-2-yl)-2-methylpropionate

1-benzyl-2-trifluoromethylpyrrolidine-2-carbonitrile