4-Methoxy-3-methylbenzenepropanoyl chloride

Base Information

Chemical Name:4-Methoxy-3-methylbenzenepropanoyl chloride
CAS No.:344308-94-7
Molecular Formula:C₁₁H₁₃ClO₂
Molecular Weight:212.676
Hs Code.:
DSSTox Substance ID:DTXSID001262314

Synonyms:4-Methoxy-3-methylbenzenepropanoyl chloride;344308-94-7;SCHEMBL11998980;DTXSID001262314

Suppliers and Price of 4-Methoxy-3-methylbenzenepropanoyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Methoxy-3-methylbenzenepropanoyl chloride

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:212.0604073
Heavy Atom Count:14
Complexity:194

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)CCC(=O)Cl)OC

Technology Process of 4-Methoxy-3-methylbenzenepropanoyl chloride

There total 4 articles about 4-Methoxy-3-methylbenzenepropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22442-47-3
3-(4-methoxy-3-methylphenyl)propinoic acid

: 344308-94-7
3-(4-Methoxy-3-methyl-phenyl)-propionyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo000458j

Reference yield:

: 32723-67-4
3-methyl-4-anisaldehyde

: 344308-94-7
3-(4-Methoxy-3-methyl-phenyl)-propionyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / toluene / 48 h / Heating

2: 98 percent / H₂ / Pd/C / ethyl acetate / 24 h / 20 °C

3: 98 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 4.5 h / 0 °C

4: oxalyl chloride / CH₂Cl₂ / 3 h / 20 °C

With lithium hydroxide; oxalyl dichloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; 1: Addition / 2: Hydrogenation / 3: Hydrolysis / 4: Substitution;
DOI:10.1021/jo000458j

Reference yield:

: 178676-97-6
ethyl (2E)-3-(4-methoxy-3-methylphenyl)acrylate

: 344308-94-7
3-(4-Methoxy-3-methyl-phenyl)-propionyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / H₂ / Pd/C / ethyl acetate / 24 h / 20 °C

2: 98 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 4.5 h / 0 °C

3: oxalyl chloride / CH₂Cl₂ / 3 h / 20 °C

With lithium hydroxide; oxalyl dichloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 1: Hydrogenation / 2: Hydrolysis / 3: Substitution;
DOI:10.1021/jo000458j