4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

Base Information

Chemical Name:4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester
CAS No.:1380664-97-0
Molecular Formula:C₃₀H₃₃N₃O₉S
Molecular Weight:611.673
Hs Code.:

4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

Synonyms:4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

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Chemical Property of 4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

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Technology Process of 4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

There total 12 articles about 4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380664-96-9
ethyl 5-(benzoyloxy)-2-(1-(benzyloxycarbonylamino)-4,4-bis(tosyloxymethyl)cyclohexyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate

: 1380664-97-0
4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 16h;

Reference yield:

: 1380664-95-8
ethyl 2-(1-(benzyloxycarbonylamino)-4,4-bis(tosyloxymethyl)cyclohexyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate

: 1380664-97-0
4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In toluene; for 1.5h; Reflux;

Reference yield:

: 55704-60-4
4-oxo-cyclohexane-1,1-dicarboxylic acid diethyl ester

: 1380664-97-0
4,6,7,8,9,10-hexahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-10-[[(phenylmethoxy)carbonyl]amino]-,7,10-ethanopyrimido[1,2-a]azepine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid / benzene / 48 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice

2.2: 1.5 h / -5 - 30 °C

3.1: pyridine / dmap / 48 h / 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 52 °C

5.1: ammonium hydroxide; ammonium chloride / tetrahydrofuran; methanol

6.1: sodium carbonate monohydrate / dichloromethane; water / 2.5 h / 20 °C / Inert atmosphere

7.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux

8.1: tetrahydrofuran / Reflux

9.1: dichloromethane; xylene / 24 h / 115 °C

10.1: N,N,N',N'-tetramethylguanidine / toluene / 1.5 h / Reflux

With pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sodium carbonate monohydrate; water; hydroxylamine; ammonium chloride; N,N,N',N'-tetramethylguanidine; dmap; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; xylene; benzene;