4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

Base Information

Chemical Name:4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one
CAS No.:1312572-51-2
Molecular Formula:C₂₀H₂₂N₆OS₂
Molecular Weight:426.566
Hs Code.:

Synonyms:4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

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Chemical Property of 4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

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Technology Process of 4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

There total 8 articles about 4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 49844-93-1
2-chloro-4-(methylsulfanyl)pyrimidine

: 1312572-68-1
4-[5-(3-amino-5-methylphenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

: 1312572-51-2
4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

Guidance literature:: With potassium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tert-Amyl alcohol; at 90 ℃; Inert atmosphere; sealed vial;

Reference yield:

: 74586-53-1
3-bromo-5-methylaniline

: 1312572-51-2
4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 20 - 80 °C / Inert atmosphere

2: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere; sealed flask

3: potassium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol / 90 °C / Inert atmosphere; sealed vial

With potassium acetate; potassium carbonate; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; tert-Amyl alcohol;

Reference yield:

: 44981-94-4
N-cyanoethyl glycine ethyl ester

: 1312572-51-2
4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloroform / 20 °C

2.1: hydrogen; ammonia / Rany-Ni / ethanol / 5 h / 20 °C

3.1: sodium methylate; methanol / 1.5 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 10 °C

4.2: 100 °C

5.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere; sealed flask

6.1: potassium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol / 90 °C / Inert atmosphere; sealed vial

With methanol; ammonia; hydrogen; sodium methylate; potassium carbonate; caesium carbonate; trifluoroacetic acid; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; tert-Amyl alcohol; ethanol; dichloromethane; chloroform;