(1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol

Base Information

Chemical Name:(1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol
CAS No.:615268-30-9
Molecular Formula:C₃₄H₃₆NO₇P
Molecular Weight:601.636
Hs Code.:

Synonyms:(1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol

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Chemical Property of (1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol

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Technology Process of (1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol

There total 9 articles about (1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35380-17-7
4,4-diphenylcyclohexanone oxime

: 615268-30-9
(1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 28 percent / trichloroisocyanuric acid; NaHCO₃ / H₂O; ethyl acetate / 24 h / 20 °C

2: 48 percent / NaBH₄ / Pd/C / ethanol / 1 h / 20 °C

3: 50 percent / NaOH; cetyl ammonium bromide / tetrahydrofuran; H₂O / 12 h / 20 °C

4: 62 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

5: 87 percent / (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol; borane dimethyl sulfide complex / tetrahydrofuran / 0.83 h / Heating

6: DMAP / CH₂Cl₂ / 20 °C

7: HF / acetonitrile; H₂O / 0.08 h / 20 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; (S)-diphenylprolinol; dimethylsulfide borane complex; trichloroisocyanuric acid; hydrogen fluoride; cetyl ammonium bromide; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; 3: Henry reaction / 4: Swern oxidation;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 4528-68-1
4,4-diphenylcyclohexan-1-one

: 615268-30-9
(1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H₂O / 2 h / 20 °C

2: 28 percent / trichloroisocyanuric acid; NaHCO₃ / H₂O; ethyl acetate / 24 h / 20 °C

3: 48 percent / NaBH₄ / Pd/C / ethanol / 1 h / 20 °C

4: 50 percent / NaOH; cetyl ammonium bromide / tetrahydrofuran; H₂O / 12 h / 20 °C

5: 62 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

6: 87 percent / (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol; borane dimethyl sulfide complex / tetrahydrofuran / 0.83 h / Heating

7: DMAP / CH₂Cl₂ / 20 °C

8: HF / acetonitrile; H₂O / 0.08 h / 20 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; (S)-diphenylprolinol; dimethylsulfide borane complex; trichloroisocyanuric acid; hydrogen fluoride; hydroxylamine hydrochloride; sodium acetate; cetyl ammonium bromide; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; 4: Henry reaction / 5: Swern oxidation;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 615268-45-6
1-chloro-1-nitro-4,4-diphenylcyclohexane

: 615268-30-9
(1R)-4-diphenylphosphatoxy-4-(1'-nitro-4',4'-diphenylcyclohexyl)butan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 48 percent / NaBH₄ / Pd/C / ethanol / 1 h / 20 °C

2: 50 percent / NaOH; cetyl ammonium bromide / tetrahydrofuran; H₂O / 12 h / 20 °C

3: 62 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

4: 87 percent / (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol; borane dimethyl sulfide complex / tetrahydrofuran / 0.83 h / Heating

5: DMAP / CH₂Cl₂ / 20 °C

6: HF / acetonitrile; H₂O / 0.08 h / 20 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; (S)-diphenylprolinol; dimethylsulfide borane complex; hydrogen fluoride; cetyl ammonium bromide; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 2: Henry reaction / 3: Swern oxidation;
DOI:10.1016/j.tet.2006.03.063