(1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane

Base Information

Chemical Name:(1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane
CAS No.:615268-50-3
Molecular Formula:C₄₀H₅₀NO₇PSi
Molecular Weight:715.899
Hs Code.:

Synonyms:(1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane

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Technology Process of (1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane

There total 8 articles about (1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 615268-49-0
(1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

: 615268-50-3
(1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;
DOI:10.1021/ol035564x

Reference yield:

: 35380-17-7
4,4-diphenylcyclohexanone oxime

: 615268-50-3
(1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane

Guidance literature:: Multi-step reaction with 6 steps

1: 28 percent / trichloroisocyanuric acid; NaHCO₃ / H₂O; ethyl acetate / 24 h / 20 °C

2: 48 percent / NaBH₄ / Pd/C / ethanol / 1 h / 20 °C

3: 50 percent / NaOH; cetyl ammonium bromide / tetrahydrofuran; H₂O / 12 h / 20 °C

4: 62 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

5: 87 percent / (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol; borane dimethyl sulfide complex / tetrahydrofuran / 0.83 h / Heating

6: DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; (S)-diphenylprolinol; dimethylsulfide borane complex; trichloroisocyanuric acid; cetyl ammonium bromide; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; 3: Henry reaction / 4: Swern oxidation;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 4528-68-1
4,4-diphenylcyclohexan-1-one

: 615268-50-3
(1R)-4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-1-diphenylphosphatoxybutane

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H₂O / 2 h / 20 °C

2: 28 percent / trichloroisocyanuric acid; NaHCO₃ / H₂O; ethyl acetate / 24 h / 20 °C

3: 48 percent / NaBH₄ / Pd/C / ethanol / 1 h / 20 °C

4: 50 percent / NaOH; cetyl ammonium bromide / tetrahydrofuran; H₂O / 12 h / 20 °C

5: 62 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

6: 87 percent / (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol; borane dimethyl sulfide complex / tetrahydrofuran / 0.83 h / Heating

7: DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; (S)-diphenylprolinol; dimethylsulfide borane complex; trichloroisocyanuric acid; hydroxylamine hydrochloride; sodium acetate; cetyl ammonium bromide; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; 4: Henry reaction / 5: Swern oxidation;
DOI:10.1016/j.tet.2006.03.063