methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate
CAS No.:1439357-06-8
Molecular Formula:C₂₃H₂₂FNO₃
Molecular Weight:379.431
Hs Code.:

Synonyms:methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

Suppliers and Price of methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

There total 6 articles about methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 31144-23-7
N-cyclohexylbenzimidoyl chloride

: 185302-85-6
methyl 3-(2,4-difluorophenyl)-3-oxopropanoate

: 1439357-06-8
methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: N-cyclohexylbenzimidoyl chloride; methyl 3-(2,4-difluorophenyl)-3-oxopropanoate; With potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

In N,N-dimethyl-formamide; at 120 ℃; for 6h;
DOI:10.1039/c3cc41690a

Reference yield:

: 72482-64-5
2,4-difluorobenzoyl chloride

: 1439357-06-8
methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 10 - 50 °C / Inert atmosphere

1.2: 0 - 70 °C / Inert atmosphere

1.3: pH 5 - 6

2.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 6 h / 120 °C

With potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; magnesium chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3cc41690a

Reference yield:

: 1583-58-0
2,4-difluoro-benzoic acid

: 1439357-06-8
methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 10 - 50 °C / Inert atmosphere

2.2: 0 - 70 °C / Inert atmosphere

2.3: pH 5 - 6

3.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 6 h / 120 °C

With thionyl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; magnesium chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3cc41690a