2933-81-5

Basic information

• Product Name: Ethanol, 2-[(4-chlorophenyl)amino]-
• Synonyms: N-(2-hydroxyethyl)-p-chloroaniline;N-(p-chlorophenyl)aminoethanol;2-(4-chlorophenylamino)ethanol;2-(4-chloro-anilino)-ethanol;2-(4-chloroanilino)ethan-1-ol;4-chloro-N-hydroxyethyl aniline
• CAS NO: 2933-81-5
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Mol File: 2933-81-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[(4-chlorophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[(4-chlorophenyl)amino]-(2933-81-5)
• EPA Substance Registry System: Ethanol, 2-[(4-chlorophenyl)amino]-(2933-81-5)

Safety Data

• Hazardous Substances Data: 2933-81-5(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 107-07-3 2-chloro-ethanol 
• 7462-17-1 2-(4-chlorophenoxy)-N-(2-hydroxyethyl)acetamide 
• 96-49-1 [1,3]-dioxolan-2-one 
• 106-39-8 bromochlorobenzene 
• 141-43-5 ethanolamine 
• 540-51-2 2-bromoethanol 
• 637-87-6 1-Chloro-4-iodobenzene 
• 5198-49-2 3-(4-chloro-phenyl)-oxazolidin-2-one 
• 25217-18-9 1-chloro-2-(4-chloro-phenylcarbamoyloxy)-ethane 
• 7732-18-5 water 
• 64-17-5 ethanol 
• 52316-60-6 2-hydroxyethylchloramine 
• 108-90-7 chlorobenzene 

Downstream Products

• 19853-57-7 3-(4-chloro-phenyl)-2-phenyl-[1,3,2]oxazaphospholidine 
• 5198-49-2 3-(4-chloro-phenyl)-oxazolidin-2-one 
• 1374779-29-9 C₂₉H₂₆Cl₂N₂O₅S 
• 1608459-95-5 C₁₃H₁₈ClNO₃ 
• 4902-32-3 2-((4-chlorophenyl)(methyl)amino)ethan-1-ol 
• 1374777-53-3 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid 

Relevant articles and documents

Green synthesis of N-(2-hydroxyethyl)anilines by the selective alkylation reaction in H2O

Based on our previous work, a safer and more sustainable protocol for the synthesis of N-(2-Hydroxyethyl)anilines has been developed. The synthesis included the selective alkylation reaction of aniline with 2-chloroethanol in H2O, eliminating the need for any catalysts and solvents during synthesis. Comparing with our previous work, the salient features of this methodology are eco-friendliness, economic benefit, and the ease of obtaining target compounds. The selective alkylation reaction in H2O is amenable to scale-up for the synthesis of N-(2-Hydroxyethyl)anilines.

Amide compound for prevention and treatment of mental disorders

The present invention relates to an amide compound for prevention and treatment of mental disorders, which is shown as a formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof, a solvate thereof, a deuterated substance or a stereoisomer thereof. Wherein R1, R2, R3, R4, R5, Ar1, Ar2, p and q are as defined in the specification. The invention also relates to a preparation methodof the amide compound, a pharmaceutical composition and a pharmaceutical preparation containing the amide compound, and an application of the compound in preparation of a drug for prevention or treatment of mental disorders such as depression, depression and anxiety, and schizophrenia.

N-Arylazetidines: Preparation through Anionic Ring Closure

We report herein an efficient synthesis of diversely substituted N-aryl-2-cyanoazetidines based on an anionic ring-closure reaction. These compounds can be prepared from β-amino alcohols in enantiomerically pure form through a three-step sequence involving (i) copper-catalyzed N-arylation, (ii) N-cyanomethylation of the secondary aniline, and (iii) one-pot mesylation followed by ring closure induced by a base. This high-yielding sequence gives access to azetidines with a predictable and adjustable substitution pattern and also with predictable diastereoselectivity. These compounds are susceptible to multiple further derivatizations through Suzuki coupling or nitrile transformation, thus appearing as valuable new scaffolds for medicinal chemistry. Their rigid shape, featuring an almost planar N-arylamine and a planar four-membered ring, was revealed by both AM1 calculations and X-ray crystallography.