3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

Base Information

Chemical Name:3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole
CAS No.:1427274-62-1
Molecular Formula:C₁₇H₁₁BrCl₂F₃NS
Molecular Weight:469.152
Hs Code.:

Synonyms:3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

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Chemical Property of 3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

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Technology Process of 3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

There total 10 articles about 3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1427274-60-9
1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butan-1-one

: 1427274-62-1
3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

Guidance literature:: With triethylamine; hydroxylamine-O-sulfonic acid; In dichloromethane; water; at -15 - 0 ℃; for 0.75h;

Reference yield:

: 1154739-81-7
(E)-1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-en-1-one

: 1427274-62-1
3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 96 h / 20 °C / Inert atmosphere

2: hydroxylamine-O-sulfonic acid; potassium hydroxide / water / 0.5 h / 20 °C

With triethylamine; potassium hydroxide; hydroxylamine-O-sulfonic acid; In water;

Reference yield:

: 1427274-98-3
tert-butyl 4-carbamoyl-2-methyl-benzoate

: 1427274-62-1
3-(4-bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / toluene; 1,4-dioxane / 2 h / 100 °C

2: 0.17 h / 190 °C / Microwave irradiation

3: triethylamine / 96 h / 20 °C / Inert atmosphere

4: hydroxylamine-O-sulfonic acid; potassium hydroxide / water / 0.5 h / 20 °C

With potassium carbonate; triethylamine; potassium hydroxide; hydroxylamine-O-sulfonic acid; In 1,4-dioxane; water; toluene;