1-Fluoro-4-[(Z)-2-methoxyethenyl]benzene

Base Information

• Chemical Name: 1-Fluoro-4-[(Z)-2-methoxyethenyl]benzene
• CAS No.: 54533-37-8
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.168
• Mol file: 54533-37-8.mol

Synonyms:1-(2-methoxyethenyl)-4-fluorobenzene

Chemical Property of 1-Fluoro-4-[(Z)-2-methoxyethenyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Fluoro-4-[(Z)-2-methoxyethenyl]benzene

There total 3 articles about 1-Fluoro-4-[(Z)-2-methoxyethenyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(methoxymethyl)triphenylphosphonium chloride (4009-98-7) + 4-fluorobenzaldehyde (459-57-4) → 1-(2-methoxyethenyl)-4-fluorobenzene (54533-37-8) + 1-(2-methoxyethenyl)-4-fluorobenzene

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.333333h;

4-fluorobenzaldehyde; In tetrahydrofuran; at 20 ℃; for 16h; Overall yield = 91 %Chromat.;

DOI:10.1055/s-0036-1591963

Reference yield:

methanol (67-56-1) + 1-ethynyl-4-fluorobenzene (766-98-3) → 1-(2-methoxyethenyl)-4-fluorobenzene (54533-37-8) + 1-(2-methoxyethenyl)-4-fluorobenzene

Guidance literature:

With dicarbonyl(5-phenyldipyrrinato)rhodium; In N,N-dimethyl acetamide; at 70 ℃; for 24h; Overall yield = 84 %; Overall yield = 170 mg; diastereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.5b00561

Reference yield:

→ 1-(2-methoxyethenyl)-4-fluorobenzene (54533-37-8)

Guidance literature:

p-Fluoracetophenon;

DOI:10.1002/oms.1210090708

upstream raw materials:

methanol

1-ethynyl-4-fluorobenzene

(methoxymethyl)triphenylphosphonium chloride

4-fluorobenzaldehyde

Refernces

• 1、 Lam, Raphael H.,Walker, D. Barney,Tucker, Matthew H.,Gatus, Mark R. D.,Bhadbhade, Mohan,Messerle, Barbara A.. "Intermolecular Hydroalkoxylation of Terminal Alkynes Catalyzed by a Dipyrrinato Rhodium(I) Complex with Unusual Selectivity". supporting information. p. 4312 - 4317. Retrieved 2015/09/22.