Multi-step reaction with 6 steps
1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; triethylamine / 4.5 h / 100 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / triethylamine / 4 h / 100 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; triethylamine; N,N-dimethyl-formamide;