2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide

Base Information

• Chemical Name: 2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide
• CAS No.: 365213-58-7
• Molecular Formula: C₁₇H₁₇N₃O
• Molecular Weight: 279.341
• Mol file: 365213-58-7.mol

Synonyms:2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide

Chemical Property of 2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide is an impurity of Zolpidem (Z650000) which is a selective non-benzodiazepine GABAA receptor agonist, a sedative and is a controlled substance (depresssant).

Technology Process of 2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide

There total 3 articles about 2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide (151-50-8) + dimethyl-(6-methyl-2-p-tolylimidazo[1,2-a]pyridin-3-ylmethyl)-amine (106961-33-5) → 6-methyl-3-cyanomethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine (768398-03-4) + 2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide (365213-58-7)

Guidance literature:

dimethyl-(6-methyl-2-p-tolylimidazo[1,2-a]pyridin-3-ylmethyl)-amine; With methyl iodide; In ethanol; at 20 ℃; for 24h;

potassium cyanide; In ethanol; water; for 4h; Heating;

Reference yield:

C17H15ClN2O (371165-45-6) + dimethyl amine (124-40-3) → N,N-dimethyl-2-[7-methyl-2-(4-methylphenyl)imidazo[1,2-α]pyridine-3-yl]acetamide + 2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide (365213-58-7) + N-methyl-2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetamide (82644-31-3) + N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide (82626-48-0)

Guidance literature:

C₁₇H₁₅ClN₂O; dimethyl amine; In dichloromethane; at 10 ℃; for 2h;

With sodium hydroxide; In water; at 30 ℃; for 2h; pH=9.6;

Reference yield:

6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine (88965-00-8) → 2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide (365213-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 78 percent / acetic acid / H₂O / 4 h / 50 - 55 °C

2.1: MeI / ethanol / 24 h / 20 °C

2.2: H₂O; ethanol / 4 h / Heating

With acetic acid; methyl iodide; In ethanol; water;

upstream raw materials:

potassium cyanide

dimethyl-(6-methyl-2-p-tolylimidazo[1,2-a]pyridin-3-ylmethyl)-amine

6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine

C₁₇H₁₅ClN₂O

Downstream raw materials:

6-methyl-2-(4-methylphenyl)-imidazo<1,2-a>pyridine-3-acetic acid

N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide