1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide

Base Information

Chemical Name:1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide
CAS No.:138850-44-9
Molecular Formula:C₁₈H₂₁N₂O₂*I
Molecular Weight:424.281
Hs Code.:

Synonyms:1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide

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Chemical Property of 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide

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Technology Process of 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide

There total 6 articles about 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 132898-87-4
6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridine

: 74-88-4
methyl iodide

: 138850-44-9
1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide

Guidance literature:: In acetonitrile; Heating;
DOI:10.1016/S0040-4020(01)80884-X

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 138850-44-9
1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / CuI, triethylamine / Pd(PPh₃)2Cl₂ / 20 h / 100 °C

2: 70 percent / 0.1 N aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature

3: tetrahydrofuran / 24 h / Heating

4: ZnCl₂, NaBH₃CN / methanol / 2 h / Ambient temperature

5: aq. ethanol / 48 h / Heating

6: 98 percent / acetonitrile / Heating

With sodium hydroxide; copper(l) iodide; sodium cyanoborohydride; triethylamine; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1016/S0040-4020(01)80884-X

Reference yield:

: 97308-49-1
2-trimethylsilylethynyl-3-pyridinecarbonitrile

: 138850-44-9
1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / 0.1 N aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature

2: tetrahydrofuran / 24 h / Heating

3: ZnCl₂, NaBH₃CN / methanol / 2 h / Ambient temperature

4: aq. ethanol / 48 h / Heating

5: 98 percent / acetonitrile / Heating

With sodium hydroxide; sodium cyanoborohydride; zinc(II) chloride; In tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1016/S0040-4020(01)80884-X