Technology Process of 4-[(2-di-N,N-methylamino)vinyl]-2-methoxy-3-nitropyridine
There total 6 articles about 4-[(2-di-N,N-methylamino)vinyl]-2-methoxy-3-nitropyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanol; copper(l) iodide; propanoic acid methyl ester;
In
tetrahydrofuran;
at 30 - 72 ℃;
for 21h;
Large scale;
DOI:10.1021/acs.oprd.7b00134
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale
2.1: sodium nitrite; chloro-trimethyl-silane / 18 h / 0 - 25 °C / Large scale
2.2: 8 h / 20 - 65 °C / Large scale
3.1: N,N-dimethyl-formamide / 80 - 100 °C / Large scale
4.1: methanol; propanoic acid methyl ester; copper(l) iodide / tetrahydrofuran / 21 h / 30 - 72 °C / Large scale
With
methanol; copper(l) iodide; chloro-trimethyl-silane; propanoic acid methyl ester; sulfuric acid; nitric acid; sodium nitrite;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
3.1: |Leimgruber-Batcho Indole Synthesis;
DOI:10.1021/acs.oprd.7b00134
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium acetate; bromine / acetic acid; water / 8 h / 25 - 30 °C / Large scale
2.1: sulfuric acid / 1 h / 10 - 33 °C / Large scale
3.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale
4.1: sodium nitrite; chloro-trimethyl-silane / 18 h / 0 - 25 °C / Large scale
4.2: 8 h / 20 - 65 °C / Large scale
5.1: N,N-dimethyl-formamide / 80 - 100 °C / Large scale
6.1: methanol; propanoic acid methyl ester; copper(l) iodide / tetrahydrofuran / 21 h / 30 - 72 °C / Large scale
With
methanol; copper(l) iodide; chloro-trimethyl-silane; propanoic acid methyl ester; sulfuric acid; bromine; nitric acid; sodium acetate; sodium nitrite;
In
tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;
5.1: |Leimgruber-Batcho Indole Synthesis;
DOI:10.1021/acs.oprd.7b00134
