4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester

Base Information

Chemical Name:4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester
CAS No.:117023-66-2
Molecular Formula:C₂₉H₃₁F₂NO₄
Molecular Weight:495.566
Hs Code.:

4-<3-<4-<bis(4-fluorophenyl)hydroxymethyl>-1-piperidinyl>propoxy>benzoic acid methyl ester

Synonyms:4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester

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Chemical Property of 4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester

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Technology Process of 4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester

There total 5 articles about 4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 69076-29-5
4-(3-chloropropoxy)benzoic acid methyl ester

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 117023-66-2
4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester

Guidance literature:: With sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; for 24h; Heating;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-66-2
4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 68 percent / Na₂CO₃, KI / dimethylformamide / 24 h / Heating

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a022

Reference yield:

: 111627-25-9
α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

: 117023-66-2
4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 68 percent / Na₂CO₃, KI / dimethylformamide / 24 h / Heating

With hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a022