Technology Process of 2-benzylidene-6-bromo-3,3-difluoro-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide
There total 3 articles about 2-benzylidene-6-bromo-3,3-difluoro-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
toluene;
at 20 - 90 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/ja2005175
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
toluene;
B-compound was added dropwise to a mixt. of hydrazole and bicyclo-compound in anhyd. toluene at room temp., heated at 90°C for 3 h under Ar atm.; the mixt. was quenched with water, extd. with CH2Cl2, the organic layerswere washed with water (3 times), dried over anhyd. Na2SO4, evapd. unde r reduced pressure, silica gel column chromy. (CH3OH/CH2Cl2 (0-1%));
DOI:10.1021/ja2005175
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / 2 h / 80 °C
2: boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 4 h / 20 - 90 °C / Inert atmosphere
With
pyridine; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
toluene;
DOI:10.1021/ja2005175
