4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether

Base Information

• Chemical Name: 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether
• CAS No.: 548464-35-3
• Molecular Formula: C₁₈H₂₈O₂
• Molecular Weight: 276.419
• Mol file: 548464-35-3.mol

Synonyms:4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether

Chemical Property of 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether

There total 12 articles about 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(-)-menthol (2216-51-5) + p-methoxybenzyl chloride (824-94-2) → 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether (548464-35-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; at 150 ℃; for 1h; Inert atmosphere; Neat (no solvent);

DOI:10.1016/j.tet.2011.10.016

Reference yield: 93.0%

diazomethyl-trimethyl-silane (18107-18-1) + 4-(2-isopropyl-5-methyl-cyclohexyloxymethyl)-phenol (775356-24-6) → 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether (548464-35-3)

Guidance literature:

In methanol; diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jo802229p

Reference yield: 92.0%

(-)-menthol (2216-51-5) + (4-methoxybenzyl)(4-nitrophenyl)sulfane (100867-01-4) → 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether (548464-35-3)

Guidance literature:

With rhodium (II) octanoate dimer; 2,6-di-tert-butyl-4-methylpyridinium trifluoromethanesulfonate; methyl 2-(4-chlorophenyl)-2-diazoacetate; In dichloromethane; at 0 ℃; for 0.5h; Molecular sieve;

DOI:10.1016/j.cclet.2021.06.069

upstream raw materials:

(-)-menthol

4-Methoxybenzyl alcohol

O-(4-methoxybenzyl)-trichloroacetimidate

p-Methoxybenzyl bromide

Downstream raw materials:

N-[(4-methoxyphenyl)methyl]-4-methylbenzenesulfonamide

(-)-menthol