tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate

Base Information

• Chemical Name: tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate
• CAS No.: 380899-36-5
• Molecular Formula: C₂₂H₂₈FN₃O₃S
• Molecular Weight: 433.547
• Mol file: 380899-36-5.mol

Synonyms:tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate

Chemical Property of tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate

There total 2 articles about tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-fluoro-phenyl)-2-methyl-thazole-4-carbonyl chloride (380899-53-6) + (S)-tert-butyl (piperidin-2-ylmethyl)carbamate (139004-93-6) → tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate (380899-36-5)

Guidance literature:

With triethylamine; In dichloromethane; at 18 - 24 ℃; for 61h;

Reference yield:

5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid (433283-22-8) → tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate (380899-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 6 h / 20 °C

2: triethylamine / dichloromethane / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmcl.2011.06.086

Reference yield:

tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate (380899-36-5) → C17H20FN3OS (380899-51-4)

Guidance literature:

tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate; With trifluoroacetic acid; In dichloromethane; at 19 - 21 ℃;

With sodium carbonate; In dichloromethane; water; at 20 ℃;

upstream raw materials:

5-(4-fluoro-phenyl)-2-methyl-thazole-4-carbonyl chloride

(S)-tert-butyl (piperidin-2-ylmethyl)carbamate

5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid

Downstream raw materials:

C₁₇H₂₀FN₃OS