1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine

Base Information

• Chemical Name: 1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine
• CAS No.: 236406-21-6
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.32
• Hs Code.: 2933399090
• Mol file: 236406-21-6.mol

Synonyms:4-Hydroxymethyl-4-methylpiperidine-1-carboxylicacid tert-butyl ester

Chemical Property of 1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 312.418°C at 760 mmHg
• PKA: 14.94±0.10(Predicted)
• Flash Point: 142.745°C
• PSA: 49.77000
• Density: 1.034g/cm³
• LogP: 1.95380
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine

There total 8 articles about 1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid (189321-63-9) → 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester (236406-21-6)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 18h; Inert atmosphere;

Reference yield: 97.0%

4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester (724790-59-4) → 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester (236406-21-6)

Guidance literature:

4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.25h;

With methanol; In tetrahydrofuran;

Reference yield: 95.0%

ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate (189442-87-3) → 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester (236406-21-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2015.08.051

upstream raw materials:

ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate

4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Downstream raw materials:

N-tert-Butoxycarbonyl-4-methyl-4-piperidine carboxaldehyde

tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid

(4-methylpiperidin-4-yl)methanol

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