N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide

Base Information

Chemical Name:N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide
CAS No.:128018-20-2
Molecular Formula:C₂₇H₃₇N₃O₄
Molecular Weight:467.608
Hs Code.:

Synonyms:N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide

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Technology Process of N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide

There total 6 articles about N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 128018-44-0
N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane

: 128018-18-8
L-proline tert-butylamide

: 128018-20-2
N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide

Guidance literature:: With triethylamine; In methanol;
DOI:10.1021/ja982893p

Reference yield: 48.0%

: 128018-20-2
N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide

Guidance literature:

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 128018-20-2
N-<1-phenyl-2(S)-<(benzyloxycarbonyl)amino>-3(R)-hydroxybutan>-4-L-prolyl-tert-butyl amide

Guidance literature:: Multi-step reaction with 5 steps

1: NMM / tetrahydrofuran

2: 2.) HCl / 1.) Et₂O

3: NaBH₄ / ethanol

4: 96 percent / NaOMe / methanol

5: 90 percent / Et₃N / methanol

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; sodium methylate; triethylamine; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/ja982893p