C₂₃H₂₉N₅O₃

Base Information

• Chemical Name: C₂₃H₂₉N₅O₃
• CAS No.: 1558037-55-0
• Molecular Formula: C₂₃H₂₉N₅O₃
• Molecular Weight: 423.515
• Mol file: 1558037-55-0.mol

Synonyms:C₂₃H₂₉N₅O₃

Chemical Property of C₂₃H₂₉N₅O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₉N₅O₃

There total 8 articles about C₂₃H₂₉N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

C20H27N5O2 (1558038-70-2) + acrylic acid (79-10-7) → C23H29N5O3 (1558037-55-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

tert-butyl 3-methylidenepyrrolidine-1-carboxylate (114214-71-0) → C23H29N5O3 (1558037-55-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: zinc/copper couple / diethyl ether; 1,2-dimethoxyethane / 48 h / 10 - 20 °C / Inert atmosphere

2.1: zinc; ammonium chloride / methanol / 8 h / 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 20 °C

4.1: pyridine / dichloromethane / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 18 h / 70 °C

6.1: hydrido(dimethylphosphinous acid κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / water; ethanol / 72 h / 80 °C

6.2: 1 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With pyridine; sodium tetrahydroborate; hydrido(dimethylphosphinous acid κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); zinc/copper couple; sodium hydride; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester (1239319-91-5) → C23H29N5O3 (1558037-55-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 18 h / 70 °C

3.1: hydrido(dimethylphosphinous acid κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / water; ethanol / 72 h / 80 °C

3.2: 1 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With pyridine; hydrido(dimethylphosphinous acid κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

tert-butyl 3-methylidenepyrrolidine-1-carboxylate

tert-butyl 1,1-dichloro-2-oxo-6-azaspiro[3.4]octane-6-carboxylate

6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester

2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester