2-(2,3-dichlorophenyl)-1,3-thiazole-4-carboxylic Acid

Base Information

Chemical Name:2-(2,3-dichlorophenyl)-1,3-thiazole-4-carboxylic Acid
CAS No.:257876-07-6
Molecular Formula:C10H5Cl2NO2S
Molecular Weight:274.127
Hs Code.:
European Community (EC) Number:674-621-6
DSSTox Substance ID:DTXSID60372513
Wikidata:Q82160263
Mol file:257876-07-6.mol

Synonyms:257876-07-6;2-(2,3-dichlorophenyl)-1,3-thiazole-4-carboxylic Acid;2-(2,3-Dichloro-phenyl)-thiazole-4-carboxylic acid;2-(2,3-Dichlorophenyl)thiazole-4-carboxylic acid;Oprea1_513535;SCHEMBL3538271;DTXSID60372513;ANTJCNIMRNBFMJ-UHFFFAOYSA-N;MFCD00208015;MS-22007;CS-0333435;FT-0732630;EN300-3283739;J-016131

Suppliers and Price of 2-(2,3-dichlorophenyl)-1,3-thiazole-4-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2,3-Dichloro-phenyl)-thiazole-4-carboxylicAcid
10mg
$ 75.00

American Custom Chemicals Corporation
2-(2,3-DICHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID 95.00%
100MG
$ 693.69

Alichem
2-(2,3-Dichlorophenyl)thiazole-4-carboxylicacid
10g
$ 1552.76

Alichem
2-(2,3-Dichlorophenyl)thiazole-4-carboxylicacid
5g
$ 1285.25

Alichem
2-(2,3-Dichlorophenyl)thiazole-4-carboxylicacid
1g
$ 456.87

Total 10 raw suppliers

Chemical Property of 2-(2,3-dichlorophenyl)-1,3-thiazole-4-carboxylic Acid

Chemical Property:

Vapor Pressure:2.56E-10mmHg at 25°C
Melting Point:233 °C
Refractive Index:1.658
Boiling Point:487.5 °C at 760 mmHg
Flash Point:248.7 °C
PSA：78.43000
Density:1.576 g/cm³
LogP:3.81510
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:272.9418050
Heavy Atom Count:16
Complexity:280

Purity/Quality:

97% ^*data from raw suppliers

2-(2,3-Dichloro-phenyl)-thiazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)Cl)Cl)C2=NC(=CS2)C(=O)O
Uses 2-(2,3-Dichloro-phenyl)-thiazole-4-carboxylic Acid can be used as SHP2 phophatase inhibitors.

Technology Process of 2-(2,3-dichlorophenyl)-1,3-thiazole-4-carboxylic Acid

There total 3 articles about 2-(2,3-dichlorophenyl)-1,3-thiazole-4-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1113-59-3
bromopyruvic acid

: 84863-83-2
2,3-dichlorobenzothioamide

: 257876-07-6
2-(2,3-dichlorophenyl)thiazole-4-carboxylic acid

Guidance literature:: In 1,4-dioxane; for 2h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 175276-86-5
2-(2,3-dichloro-phenyl)-thiazole-4-carboxylic acid ethyl ester

: 257876-07-6
2-(2,3-dichlorophenyl)thiazole-4-carboxylic acid

Guidance literature:: 2-(2,3-dichloro-phenyl)-thiazole-4-carboxylic acid ethyl ester; With methanol; lithium hydroxide; water; for 4h; Heating / reflux;

With hydrogenchloride; In water; pH=2; Product distribution / selectivity;

Reference yield:

: 5980-24-5
2,3-dichlorobenzamide

: 257876-07-6
2-(2,3-dichlorophenyl)thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Lawessons reagent / tetrahydrofuran / Reflux

2: tetrahydrofuran / 14 h / 70 °C

With Lawessons reagent; In tetrahydrofuran;
DOI:10.1016/j.bmc.2020.115990