benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

Base Information

Chemical Name:benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate
CAS No.:1610370-42-7
Molecular Formula:C₂₉H₂₇FN₂O₃
Molecular Weight:470.543
Hs Code.:

Synonyms:benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

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Chemical Property of benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

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Technology Process of benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

There total 5 articles about benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1610370-41-6
2-fluoro-4'-(4-iodobenzyl)-5-methoxy-3'-methyl-1,1'-biphenyl

: 1610370-42-7
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1.66667h; Inert atmosphere;

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 1610370-42-7
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

3.2: 1.33 h / 90 °C

4.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; oxalyl dichloride; potassium carbonate; caesium carbonate; dimethyl sulfoxide; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 24078-12-4
4-bromo-2-methylbenzaldehyde

: 1610370-42-7
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

2.2: 1.33 h / 90 °C

3.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;