2,3,3,3-tetrafluoropropanoic Acid

Base Information

• Chemical Name: 2,3,3,3-tetrafluoropropanoic Acid
• CAS No.: 359-49-9
• Molecular Formula: C3H2F4O2
• Molecular Weight: 146.041
• Hs Code.: 29159000
• European Community (EC) Number: 671-742-6
• UNII: D0Q5TRW9MJ
• DSSTox Substance ID: DTXSID40382170
• Mol file: 359-49-9.mol

Synonyms:2,3,3,3-tetrafluoropropanoic Acid;359-49-9;2,3,3,3-tetrafluoropropionic acid;2,3,3,3-TETRAFLUOROPROPANOICACID;D0Q5TRW9MJ;Propanoic acid, 2,3,3,3-tetrafluoro-;UNII-D0Q5TRW9MJ;2h-tetrafluoropropionic acid;SCHEMBL301057;PFCA-H;C3H2F4O2;DTXSID40382170;MFCD01328323;2,3,3,3-tetrafluoro-propionic acid;AKOS005173377;FS-5783;2,3,3,3-tetrakis(fluoranyl)propanoic acid;Hydrogen-substituted perfluoropropanoic acid;FT-0676520;EN300-180188;2,3,3,3-Tetrafluoropropanoic acid, AldrichCPR;A823058

Chemical Property of 2,3,3,3-tetrafluoropropanoic Acid

Chemical Property:

• Vapor Pressure: 7.79mmHg at 25°C
• Melting Point: 28.2 °C
• Refractive Index: 1.306
• Boiling Point: 124.8 °C at 760 mmHg
• Flash Point: 29.3 °C
• PSA: 37.30000
• Density: 1.538 g/cm³
• LogP: 0.97140
• Sensitive.: Hygroscopic
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 145.99909195
• Heavy Atom Count: 9
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

2,3,3,3-TetrafluoropropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C，Xi
• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)O)(C(F)(F)F)F

Technology Process of 2,3,3,3-tetrafluoropropanoic Acid

There total 6 articles about 2,3,3,3-tetrafluoropropanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

perfluoropropylene (116-15-4,13429-24-8,25120-07-4,6792-31-0) → 2,3,3,3-tetrafluoropropionic acid (359-49-9) + 2H-tetrafluoropropionylfluorosulfate (40416-27-1) + 1,2,2-trifluoro-2-hydroxy-1-trifluoromethylethanesulfonic acid sultone (773-15-9)

Guidance literature:

With sulfuric acid; at 42 ℃; for 6h;

DOI:10.1016/S0022-1139(03)00005-8

Reference yield: 47.2%

1,1-dibromo-1,2,2,2-tetrafluoroethane (27336-23-8) + carbon dioxide (124-38-9,18923-20-1) → 2,3,3,3-tetrafluoropropionic acid (359-49-9) + 2-bromo-2,3,3,3-tetrafluoro-propionic acid (13859-31-9)

Guidance literature:

With water; hydrogen cation; zinc; In N,N-dimethyl-formamide; for 6h; irradiated by ultrasound;

DOI:10.1016/S0022-1139(00)85074-5

Reference yield: 35.0%

1,1,1,2,tetrafluoro-2-fluorocarbonylethansulfinylfluoride (27825-79-2) + dihydrogen peroxide (7722-84-1) → 2,3,3,3-tetrafluoropropionic acid (359-49-9) + 1,2,2,2-tetrafluoro-ethanesulfonic acid (20705-83-3) + trifluoroacetic acid (76-05-1)

Guidance literature:

at 90°C, 35 % H2O2 used;

DOI:10.1016/S0040-4039(01)97954-7

upstream raw materials:

1-bromo-1-chloro-1,2,2,2-tetrafluoro-ethane

carbon dioxide

1,1-dibromo-1,2,2,2-tetrafluoroethane

3-hydroheptafluoro-2-butanone

Downstream raw materials:

2-bromo-2,3,3,3-tetrafluoro-propionic acid

Refernces

• 1、 Cheburkov, Yuri,Lamanna, William M.. "Fluorinated olefins and oleum". . p. 147 - 152. Retrieved 2007/10/03.