2,4,6-TRIMETHOXYBENZYL ALCOHOL

Base Information

• Chemical Name: 2,4,6-TRIMETHOXYBENZYL ALCOHOL
• CAS No.: 61040-78-6
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Hs Code.: 2909499000
• Mol file: 61040-78-6.mol

Synonyms:2,4,6-Trimethoxybenzenemethanol;2,4,6-Trimethoxybenzyl alcohol;

Chemical Property of 2,4,6-TRIMETHOXYBENZYL ALCOHOL

Chemical Property:

• Vapor Pressure: 8.92E-05mmHg at 25°C
• Melting Point: 58-61°C
• Refractive Index: 1.513
• Boiling Point: 326.2 °C at 760 mmHg
• PKA: 13.92±0.10(Predicted)
• Flash Point: 151.1 °C
• PSA: 47.92000
• Density: 1.131 g/cm³
• LogP: 1.20470
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,4,6-TrimethoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,6-TRIMETHOXYBENZYL ALCOHOL

There total 3 articles about 2,4,6-TRIMETHOXYBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4,6-trimethoxybenzaldehyde (830-79-5) → 2,4,6-trimethoxybenzyl alcohol (61040-78-6)

Guidance literature:

With formic acid; C₂₀H₂₉ClIrN₄⁽¹⁺⁾*Cl^(1-); In water; at 80 ℃; for 0.333333h; chemoselective reaction;

DOI:10.1039/c7gc01289f

Reference yield:

potassium acetate (127-08-2) + 2,4,6-trimethoxybenzyl phenyl sulfide (197142-05-5) → 2,4,6-trimethoxybenzaldehyde (830-79-5) + 2,4,6-trimethoxybenzyl alcohol (61040-78-6) + diphenyldisulfane (882-33-7) + 2,4,6-trimethoxybenzyl acetate (149286-58-8)

Guidance literature:

With Co(III)W; In water; acetic acid; for 0.5h; Product distribution; Ambient temperature;

DOI:10.1016/S0040-4020(97)00560-7

Reference yield:

ethanol (64-17-5) + 2,4,6-trimethoxybenzaldehyde (830-79-5) → 2,4,6-trimethoxybenzyl alcohol (61040-78-6)

Guidance literature:

upstream raw materials:

2,4,6-trimethoxybenzaldehyde

potassium acetate

2,4,6-trimethoxybenzyl phenyl sulfide

ethanol

Downstream raw materials:

S-(2,4,6-Trimethoxybenzyl)-L-cysteine

S-(2,4,6-Trimethoxybenzyl)-L-cysteine trifluoroacetate

2,4,6-trimethoxybenzyl thioacetate

3-Methyl-3-[(2,4,6-trimethoxyphenyl)methylthio]butanoic acid

Refernces

• 1、 Fuchs, Olaf,Hanebrink, Hendrik,Reimann, Marc,Seitz, Oliver,Trunschke, Sebastian. "Enabling Cysteine-Free Native Chemical Ligation at Challenging Junctions with a Ligation Auxiliary Capable of Base Catalysis". supporting information. p. 19483 - 19490. Retrieved 2021/08/09.
• 2、 Hudson, Robert H.E.,Heidari, Ali,Martin-Chan, Timothy,Park, Gyeongsu,Wisner, James A.. "On the Necessity of Nucleobase Protection for 2-Thiouracil for Fmoc-Based Pseudo-Complementary Peptide Nucleic Acid Oligomer Synthesis". . p. 13252 - 13261. Retrieved 2019/11/16.