N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide

Base Information

Chemical Name:N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide
CAS No.:1229649-26-6
Molecular Formula:C₃₅H₃₈N₆O₄
Molecular Weight:606.725
Hs Code.:

Synonyms:N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide

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Chemical Property of N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide

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Technology Process of N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide

There total 6 articles about N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 2544-06-1
3-Methoxypropionic acid

: 1220627-08-6
1-(4-((2-aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

: 1229649-26-6
N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide

Guidance literature:: 3-Methoxypropionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2.16667h;

1-(4-((2-aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h;

Reference yield:

: 79-37-8
oxalyl dichloride

: 2544-06-1
3-Methoxypropionic acid

: 144-55-8
sodium hydrogencarbonate

: 1229649-26-6
N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide

Guidance literature:: With DIPEA; ammonia; SiO₂; In methanol; 2-Methylpentane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 105250-17-7
2-amino-4-hydroxymethylpyridine

: 1229649-26-6
N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-3-methoxypropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / -15 - 20 °C

2.1: acetic acid; 10% Pt/activated carbon; hydrogen / methanol / 40 °C

3.1: dichloromethane / 1.67 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2.17 h / 0 - 20 °C

4.2: 16 h

With oxalyl dichloride; di-isopropyl azodicarboxylate; 10% Pt/activated carbon; hydrogen; acetic acid; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;