(3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

Base Information

Chemical Name:(3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide
CAS No.:120059-76-9
Molecular Formula:C₂₃H₂₉N₃O₃
Molecular Weight:395.502
Hs Code.:

Synonyms:(3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

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Chemical Property of (3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

Chemical Property:

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Technology Process of (3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

There total 6 articles about (3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 123-62-6
propionic acid anhydride

: 120059-84-9
{(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

: 120059-76-9
(3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

Guidance literature:: In toluene; Heating;
DOI:10.1021/jm00126a040

Reference yield:

: 31633-72-4
methyl 3-methyl-4-oxo-1-piperidinecarboxylate

: 120059-76-9
(3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / p-toluene sulfonic acid / toluene / Heating

2: 1.) sodium metal, 2.) 48 percent HBr / 1.) methanol, reflux, 2.) reflux, 4 h

3: 62 percent / Na₂CO₃, KI / various solvent(s) / Heating

4: 86 percent / toluene / Heating

With hydrogen bromide; sodium; sodium carbonate; toluene-4-sulfonic acid; potassium iodide; In toluene;
DOI:10.1021/jm00126a040

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 120059-76-9
(3R,4R)-trans-N-<3-Methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / Na₂CO₃, KI / various solvent(s) / Heating

2: 86 percent / toluene / Heating

With sodium carbonate; potassium iodide; In toluene;
DOI:10.1021/jm00126a040