1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

Base Information

Chemical Name:1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine
CAS No.:950482-35-6
Molecular Formula:C₁₇H₁₃Cl₂F₃N₂O
Molecular Weight:389.204
Hs Code.:

Synonyms:1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

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Chemical Property of 1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

Chemical Property:

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Technology Process of 1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

There total 5 articles about 1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 950482-35-6
1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C

2.2: 18 h / 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 50 °C

3.2: pH 3

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Heating / reflux

5.1: N,N-dimethyl-formamide / 20 h / 20 °C

6.1: hydrazine / ethanol; water / 1.5 h / Heating / reflux

With sodium tetrahydroborate; N-chloro-succinimide; thionyl chloride; potassium carbonate; hydrazine; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 950482-66-3
2-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzyl}-1H-isoindol-1,3(2H)-dione

: 950482-35-6
1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

Guidance literature:: With hydrazine; In methanol; water; for 1h; Reflux;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 950482-35-6
1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C

1.2: 18 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 50 °C

2.2: pH 3

3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Heating / reflux

4.1: N,N-dimethyl-formamide / 20 h / 20 °C

5.1: hydrazine / ethanol; water / 1.5 h / Heating / reflux

With sodium tetrahydroborate; N-chloro-succinimide; thionyl chloride; hydrazine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;