N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide

Base Information

• Chemical Name: N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide
• CAS No.: 950480-77-0
• Molecular Formula: C₁₉H₁₅Cl₂F₃N₂O₂
• Molecular Weight: 431.242

Synonyms:N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide

Chemical Property of N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide

There total 3 articles about N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine (950482-35-6) + acetyl chloride (75-36-5) → N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide (950480-77-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4) + C10H11ClN2O2 → N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide (950480-77-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

Methoxyacetyl chloride (38870-89-2) + 1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine (950482-35-6) + propionyl chloride (79-03-8) + chloroformic acid ethyl ester (541-41-3) + m-Chlorobenzoyl chloride (618-46-2) + o-chlorobenzoyl chloride (609-65-4) + cyclopropanecarboxylic acid chloride (4023-34-1) + 4-chloro-benzoyl chloride (122-01-0) + acetyl chloride (75-36-5) + isobutyryl chloride (79-30-1) + methyl chloroformate (79-22-1) + chloroacetyl chloride (79-04-9) + phenyl chloroformate (1885-14-9) + isobutyl chloroformate (543-27-1) → N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylmethyl] cyclopropanecarboxamide (950479-74-0) + methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]carbamate (950481-86-4) + N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide (950480-77-0) + N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylmethyl] propionamide (950480-78-1) + N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]isobutyrylamide (950479-73-9) + chloro-N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide (950479-76-2) + N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]-2-methoxyacetamide (950479-78-4) + ethyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]carbamate (950479-81-9) + isobutyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]carbamate (950481-87-5) + phenyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]carbamate (950479-82-0) + 2-chloro-N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]benzamide (950479-92-2) + 4-chloro-N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]benzamide (950479-94-4) + 3-chloro-N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]benzamide (950479-93-3)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 24h; Combinatorial reaction / High throughput screening (HTS);

upstream raw materials:

Methoxyacetyl chloride

1-{4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl]phenyl}-methanamine

propionyl chloride

chloroformic acid ethyl ester

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