Technology Process of (2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride
There total 3 articles about (2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenylmethyl octahydroindole-2-carboxylate hydrochloride;
With
sodium hydroxide;
In
water;
pH=10.5;
Industry scale;
With
O,O'-dibenzoyl-D-tartaric acid;
In
di-isopropyl ether;
at 20 ℃;
for 1h;
Resolution of racemate;
Industry scale;
With
hydrogenchloride; sodium hydroxide;
more than 3 stages;
- Guidance literature:
-
octahydroindole-2-carboxylic acid benzyl ester hydrochloride;
With
sodium hydroxide;
In
water;
pH=10.5;
N-Cbz-L-Phe;
In
di-isopropyl ether;
at 15 - 20 ℃;
for 3h;
Resolution of racemate;
With
hydrogenchloride; sodium hydroxide;
more than 3 stages;
Purification / work up;
- Guidance literature:
-
octahydroindole-2-carboxylic acid benzyl ester hydrochloride;
With
sodium hydroxide;
In
water;
pH=10.5;
O,O'-dibenzoyl-L-tartaric acid;
In
di-isopropyl ether;
at 20 ℃;
for 1h;
Resolution of racemate;
With
hydrogenchloride; sodium hydroxide;
more than 3 stages;
Purification / work up;
