10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester

Base Information

• Chemical Name: 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester
• CAS No.: 1436841-47-2
• Molecular Formula: C₃₀H₁₉ClFNO₄
• Molecular Weight: 511.937

Synonyms:10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester

Chemical Property of 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester

There total 3 articles about 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide (1436840-94-6) + propynoic acid ethyl ester (623-47-2) → 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester (1436841-47-2)

Guidance literature:

With aluminum oxide; In chloroform; at 90 ℃; Microwave irradiation; Green chemistry;

DOI:10.1016/j.tetlet.2013.03.095

Reference yield:

5-chloro-2-(4-fluorophenyl)furo[3,2-h]quinoline (1218818-89-3) → 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester (1436841-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Reflux; Green chemistry

2: aluminum oxide / chloroform / 90 °C / Microwave irradiation; Green chemistry

With aluminum oxide; In chloroform; acetonitrile;

DOI:10.1016/j.tetlet.2013.03.095

Reference yield:

α-bromoacetophenone (70-11-1) → 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester (1436841-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Reflux; Green chemistry

2: aluminum oxide / chloroform / 90 °C / Microwave irradiation; Green chemistry

With aluminum oxide; In chloroform; acetonitrile;

DOI:10.1016/j.tetlet.2013.03.095

upstream raw materials:

5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide

propynoic acid ethyl ester

5-chloro-2-(4-fluorophenyl)furo[3,2-h]quinoline

α-bromoacetophenone

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