2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid

Base Information

Chemical Name:2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid
CAS No.:1030367-96-4
Molecular Formula:C₃₀H₂₅F₃O₃S
Molecular Weight:522.588
Hs Code.:

Synonyms:2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid

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Chemical Property of 2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid

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Technology Process of 2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid

There total 7 articles about 2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: methyl 2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetate

: 1030367-96-4
2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.06.044

Reference yield:

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

: 1030367-96-4
2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.17 h / -78 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 25 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

3.2: 0.5 h / -78 - 25 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C

5.1: potassium carbonate / water; acetone / 4 h / 25 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 0 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; water; isopropylmagnesium chloride; potassium carbonate; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1030367-87-3
2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

: 1030367-96-4
2-(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / water; acetone / 4 h / 25 °C

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 0 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; water; acetone;