(R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate
CAS No.:1442445-60-4
Molecular Formula:C₂₄H₃₀Cl₂N₄O₄
Molecular Weight:509.433
Hs Code.:

Synonyms:(R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate

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Chemical Property of (R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate

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Technology Process of (R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate

There total 3 articles about (R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1442445-38-6
(R)-N-(1-(2,4-dichlorophenyl)ethyl)-5-fluoro-2-nitroaniline

: 170033-47-3
(R)-tert-butyl 2-methylpiperazine-1-carboxylate

: 1442445-60-4
(R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 125 ℃; for 3h;

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1442445-60-4
(R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C / Resolution of racemate

1.2: 1 h / 20 °C / Resolution of racemate

2.1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

3.1: potassium carbonate / dimethyl sulfoxide / 3 h / 125 °C

With (S)-Mandelic acid; potassium carbonate; In ethanol; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 133773-29-2
(R)-2,4-dichloro-α-methylbenzylamine

: 1442445-60-4
(R)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

2: potassium carbonate / dimethyl sulfoxide / 3 h / 125 °C

With potassium carbonate; In dimethyl sulfoxide;