ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate

Base Information

Chemical Name:ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate
CAS No.:122858-41-7
Molecular Formula:C₁₅H₁₄F₂N₂O₂
Molecular Weight:292.285
Hs Code.:

Synonyms:ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate

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Chemical Property of ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate

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Technology Process of ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate

There total 5 articles about ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 544-92-3
copper(I) cyanide

: 122858-42-8
4-(4-bromo-2,5-difluorophenyl)-1-(ethoxycarbonyl)-1,2,3,6-tetrahydropyridine

: 122858-41-7
ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate

Guidance literature:: In N,N-dimethyl-formamide; for 20h; Heating;
DOI:10.1021/jm00066a005

Reference yield:

: 327-51-5
1,4-dibromo-2,5-difluorobenzene

: 122858-41-7
ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium / 1.) ethyl ether, hexane, -75 deg C, 2.) ethyl ether, hexane, -50 deg C, 30 min

2: 80 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

3: 63.5 percent / dimethylformamide / 20 h / Heating

With n-butyllithium; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00066a005

Reference yield:

: 122858-43-9
ethyl 4-(4-bromo-2,5-difluorophenyl)-4-hydroxy-1-piperidinecarboxylate

: 122858-41-7
ethyl 4-(4-cyano-2,5-difluorophenyl)-1,2,3,6-tetrahydro-1-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

2: 63.5 percent / dimethylformamide / 20 h / Heating

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00066a005