ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate

Base Information

Chemical Name:ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate
CAS No.:122858-46-2
Molecular Formula:C₁₈H₁₉F₂NO₄
Molecular Weight:351.35
Hs Code.:

Synonyms:ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate

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Chemical Property of ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate

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Technology Process of ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate

There total 9 articles about ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37517-78-5
magnesium bis(3-ethoxy-3-oxopropanoate)

: 122858-15-5
4-(1-acetyl-1,2,3,6-tetrahydro-4-pyridinyl)-2,5-difluorobenzoic acid

: 122858-46-2
ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate

Guidance literature:: With hydrogenchloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 327-51-5
1,4-dibromo-2,5-difluorobenzene

: 122858-46-2
ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-butyllithium / 1.) ethyl ether, hexane, -75 deg C, 2.) ethyl ether, hexane, -50 deg C, 30 min

2: 80 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

3: 63.5 percent / dimethylformamide / 20 h / Heating

4: 9.95 g / 6N HCl / 23 h / Heating

5: 77 percent / 0.75 h / Heating

6: tetrahydrofuran / 1.5 h / Ambient temperature

7: tetrahydrofuran / 1) RT, overnight, 2.) reflux, 1.5 h

With hydrogenchloride; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00066a005

Reference yield:

: 122858-42-8
4-(4-bromo-2,5-difluorophenyl)-1-(ethoxycarbonyl)-1,2,3,6-tetrahydropyridine

: 122858-46-2
ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,5-difluoro-β-oxobenzenepropionate

Guidance literature:: Multi-step reaction with 5 steps

1: 63.5 percent / dimethylformamide / 20 h / Heating

2: 9.95 g / 6N HCl / 23 h / Heating

3: 77 percent / 0.75 h / Heating

4: tetrahydrofuran / 1.5 h / Ambient temperature

5: tetrahydrofuran / 1) RT, overnight, 2.) reflux, 1.5 h

With hydrogenchloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00066a005