(2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

Base Information

Chemical Name:(2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one
CAS No.:286936-09-2
Molecular Formula:C₁₂H₁₈O₅
Molecular Weight:242.272
Hs Code.:
Mol file:286936-09-2.mol

Synonyms:(2'S,3'S,4R,5R)-4-O,5-O-(2',3'-dimethoxybutane-2',3'-diyl)-4,5-dihydroxycyclohex-2-en-1-one

Suppliers and Price of (2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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TRC
(2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one
25mg
$ 165.00

Total 1 raw suppliers

Chemical Property of (2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

Chemical Property:

Solubility.:Chloroform, DCM

Purity/Quality:: (2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one is an intermediate in the synthesis of (-)-Altenuene (A575740), a toxin isolated from the fungus Alternaria tenuis.

Technology Process of (2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

There total 10 articles about (2S,3S,4aR,8aR)-2,3,4a,8a-Tetrahydro-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 286936-08-1
(2R,3S,4aR,8R,8aR)-8-hydroxy-2,3-dimethoxy-2,3-dimethylhexahydro-1,4-benzodioxin-6(5H)-one

: 286936-09-2
(2'S,3'S,4R,5R)-4-O,5-O-(2',3'-dimethoxybutane-2',3'-diyl)-4,5-dihydroxycyclohex-2-en-1-one

Guidance literature:: With dmap; acetic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 6h;
DOI:10.1021/ja016460p

Reference yield: 99.0%

: 334700-48-0
(2S,3S,4aR,8aR)-2,3,4a,5,6,8a-hexahydro-7-iodo-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-6-one

: 286936-09-2
(2'S,3'S,4R,5R)-4-O,5-O-(2',3'-dimethoxybutane-2',3'-diyl)-4,5-dihydroxycyclohex-2-en-1-one

Guidance literature:: With copper(l) iodide; triphenyl-arsane; tetra-n-butyltin(IV); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; at 100 ℃; for 24h;
DOI:10.1039/b103072h

Reference yield: 85.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 334700-48-0
(2S,3S,4aR,8aR)-2,3,4a,5,6,8a-hexahydro-7-iodo-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-6-one

: C₁₄H₂₀O₇

: 286936-09-2
(2'S,3'S,4R,5R)-4-O,5-O-(2',3'-dimethoxybutane-2',3'-diyl)-4,5-dihydroxycyclohex-2-en-1-one

Guidance literature:: With 2,6-dimethylpyridine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; at 60 ℃; for 48h; under 38787.1 Torr;
DOI:10.1002/anie.202009562